Figure 1.

Conservation of CoA biosynthesis pathway in all malaria parasite species. A schematic representation of the canonical biosynthesis pathway of CoA from pantothenate with enzymes PanK (Pantothenate Kinase), PPCS (Phosphopantothenylcysteine Synthase), PPCDC (Phosphopantothenylcysteine Decarboxylase), PPAT (Phosphopantetheine Adenylyltransferase), and DPCK (Dephospho-CoA Kinase), respectively. The PlasmoDB IDs for the genes encoding the biosynthesis enzymes of CoA, that are conserved by homology and synteny in all sequenced malaria parasite species, are listed under each enzyme in P. yoelii, P. falciparum, P. berghei, P. chabaudi, P. knowlesi, and P. vivax, respectively.