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Electroretinography. Five of 9 AAV-Pde6a treated eyes had a measureable scotopic threshold response (STR) on ERGs at light intensities below b-wave threshold (representative traces shown in A–C). No untreated eye or AAV-GFP injected eye had the presence of an STR. The STR in those eyes with a detectable response increased in amplitude with increasing flash luminance, and the amplitude was sustained throughout the treatment period (D).
