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. 2017 Jun 20;11:342. doi: 10.3389/fnins.2017.00342

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Copyright © 2017 Mowat, Occelli, Bartoe, Gervais, Bruewer, Querubin, Dinculescu, Boye, Hauswirth and Petersen-Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spectral domain optical coherence tomography. SD-OCT was performed on three animals injected with AAV-Pde6a at 41–42 days of age, contralateral eyes were injected with AAV-GFP. Animals were imaged at 1, 3, and 5 months post-treatment (A). The outer nuclear layer in AAV-Pde6a treated eyes was thicker compared with contralateral AAV-GFP treated eyes, and this difference was significant at 5 months post-injection (B). ^*p < 0.05, two-way repeated measures ANOVA, scale bar represents 200 μm.