Table 1.
Examples of available diblock or triblock copolymers that constitute asymmetrical polymersomes.
| Polymers | Preparation method | Formation method | Copolymers | Targeting ligands | Drugs/stimulus for release | Pros and cons | References |
|---|---|---|---|---|---|---|---|
| PEO45-b-PS130-b-PDEA120 | Atrp | None reported | PEO45-b-PS130-b-PDEA120 | None reported | pH-induced | None reported | Giacomelli et al., 2007 |
| FA/DTPA-PGA-b-PCL | None reported | Solvent switching method | FA-PGA75-b-PCL30 and DTPA-PGA22-b-PCL30 | FA | DOX·HCl/pH-induced | Improve the sensitivity of a T2 MRI contrast agent | Oerlemans et al., 2010 |
| Anis-PEG-PTTMA-PAA | Raft | Solvent switching method | Anis-PEG-PTTMA-PAA and PEG-PTTMA-PAA | Anisamide | GrB/pH-induced | Targeting ability and prompt intracellular protein release | Lu et al., 2015 |
| PEG5K-P(CL-co-LA)11K-PEG2K | Rop | Film hydration method | mPEG-PCL or mPEG-P-(CL-co-LA) | None reported | Hb | Undamaged gas-binding capability and oxygen affinity, plus high stability and biocompatibility | Kishimura et al., 2007 |
| PEO113-b-PCL132-b-PAA15 | None reported | Solvent switching method | PEO113-b-PCL132-b-PAA15 | None reported | DOX·HCl/pH-induced | High DOX loading efficiency and good biodegradability, rapid endocytosis rate and endosomal escape ability | Liu et al., 2014 |
| Acupa-PEG-PTMBPEC-PSAC | Rop | Solvent switching method | Acupa-PEG-PTMBPEC-PSAC and PEG-PTMBPEC-PSAC | 2-[3-[5-amino-2-carboxypentyl]-ureido]-pentanedioic acid | GrB/pH-induced | Unimodal distribution, high protein loading contents, long circulation time | Du et al., 2012 |
| PEG-SS-PCL-PDEA | Rop | Solvent switching method | PEG-PCL-PDEA and PEG-SS-PCL | Galactose | GrB/reduction-induced | Unimodal distribution, highly efficient loading, high protein loading contents, long circulation time, target ability | Drummond et al., 1999 |
| PB-b-PS | Atrp | Blending in an oil-in-oil emulsion | polystyrene-b-poly(ethylene oxide) (SO) and polybutadiene-b-poly-(ethylene oxide) (BO) | None reported | None reported | Straightforward preparation method | Asano et al., 2016 |
| PEG-PTTMA-PAA | Raft | Solvent switching method | PEG-PTTMA-PAA | None reported | DOX·HCl/pH-induced | Conveniently prepared, high loading efficiency, excellent biocompatibility, quickly destabilized | Du et al., 2012 |
| PEG–PAA(SH)–PDEA) | Raft | Solvent switching method | PEG–PAA(SH)–PDEA) | None reported | FITC–CC/reduction- and pH–induced | Conveniently prepared, high loading content, excellent biocompatibility | Zupancich et al., 2006 |
| PEO-PAA-PNIPAM | Raft | Solvent switching method | PEO-PAA-PNIPAM | None reported | FITC–dextran/temperature-induced | Stability against high salt conditions and change of temperature | Du and O'Reilly, 2009 |
| PEO–PDPA–PDMA | Atrp | Solvent switching method | PEO–PDPA–PDMA | None reported | None reported | None reported | Zhang and Eisenberg, 1995 |
| PEG-PCL-PDEA | Raft | Film hydration method | PEG-PCL-PDEA | None reported | FITC-CC | High protein loading efficiencies and controlled release, able to simultaneously deliver and release hydrophobic anticancer drugs and proteins into cells | Liu et al., 2010 |
| PEG-PCL-DEX | Rop | Solvent switching method | PEG-PCL and DEX-PCL | None reported | PEO | A variety of chemically dynamic characteristics responding to biological pathways | Zhang et al., 2010 |