Table 4.

Comparisons of risk allele frequencies between case and control with non-motor clinical outcomes.

Outcomes	rs2583988			rs356219			rs2736990
	T allele (%)	OR (95%CI)	p	G allele (%)	OR (95%CI)	p	C allele (%)	OR (95%CI)	p
Age at onset
EOPD	17 (23.0)	1.24 (0.64–2.36)	0.503	46 (62.0)	1.82 (1.05–3.14)	0.040	50 (68.0)	1.88 (1.07–3.29)	0.028
Controls	38 (19.3)			93 (47.4)			79 (80.6)
Cognitive impairment
PD	34 (31.0)	2.39 (1.25–4.58)	0.010	72 (67.0)	2.22 (1.29–3.84)	0.004	76 (70.0)	2.21(1.26–3.85)	0.005
Controls	18 (16.0)			53 (47.0)			58 (52.0)
Anxiety
PD	31 (23.0)	1.29 (0.62–2.66)	0.591	81 (60.0)	1.47 (0.82–2.63)	0.235	89 (65.0)	1.63 (0.55–4.85)	0.398
Controls	13 (19.0)			55 (40.0)			38 (54.0)
Depression
PD	34 (24.0)	1.31 (0.61–2.81)	0.574	80 (57.0)	1.24 (0.66–2.31)	0.527	89 (64.0)	1.59 (0.88–2.87)	0.132
Controls	11 (20.0)			29 (52.0)			32 (57.0)

OR, odds ratio; CI, confidence interval; p, significance level; EOPD, early onset Parkinson’s disease; PD, Parkinson’s disease.