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. 2017 Jun 20;7:269. doi: 10.3389/fcimb.2017.00269

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Copyright © 2017 Ma, Ye, Chen, Nie, Cheng, Zhang, Han, Wu, Xu, Lei and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy evaluation of inactive HTNV vaccines by detecting NAb titers with ICW (A,B) The NAb titers of vaccinees without boost (two primary doses, n = 8) were determined by the ICW assay (A) and ELISA (B). (C,D) The NAb titers of vaccinees in the boost group (two primary doses, n = 8) were determined by the ICW assay (C) and ELISA (D). (E) The NAb titers of vaccinees with different vaccination strategies were assessed using the ICW assay. Notably, three individuals exhibited no production of NAbs; the NAb titers of these patients were presented as 1 to calculate the geometric mean value. Data are presented as the geometric mean ± 95% CI. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 by Student's t-test.