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. 2017 Jun 20;10:196. doi: 10.3389/fnmol.2017.00196

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Copyright © 2017 Hsu, Jhang, Cheng, Chang, Mao, Yang, Lin, Chen and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurodegeneration and cell death in cerebellum of truncated mutant ATXN 3 transgenic mice. The cerebellum samples from WT (A), TSQ (B,E), and TLQ (C,F) mice were collected at 4 months of age, and then subjected to Fluoro-Jade B staining (A–C) and TUNEL staining (E,F). Arrow heads in (C) indicate degenerative neurons with green filament structure, and higher magnification image of degenerative neurons is shown in bottom left. (D) Quantitative results from (A–C) are counted from four randomly different 0.05 mm² regions. ^∗∗∗ represents p < 0.001. Arrows in (F) show TUNEL-positive dead cells. ML, molecular layer; GL, granular layer; WM, white matter. N = 3 for each group.