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. 2016 Nov 24;7:13580. doi: 10.1038/ncomms13580

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) PAGE analysis of siRNA-TRU self-assembly. Lanes 1–9 represent C1, C2, V1, R1, R2, antisense siRNA, siRNA, the mixture of lines 1–7 and DNA ladder marker. (b) PAGE analysis of siRNA-ONV self-assembly. Lanes 1–6 represent DNA primer, circular DNA template, DNA backbone, siRNA-TRU, siRNA-ONV and DNA ladder marker. (c) AFM image of siRNA-ONV. Phase image: scale bar, 300 nm.