Table 3a.

Differentially expressed miRNAs

miRNA	P‐value	FDR	Permutation P‐value	Fold change (Cachectic cases vs. non‐cachectic controls)	Direction of fold change
hsa‐let‐7d‐3p	0.01	0.21	0.01	1.48	Up
hsa‐miR‐345‐5p	0.02	0.21	0.02	1.47	Up
hsa‐miR‐423‐5p	0.009	0.21	0.009	1.42	Up
hsa‐miR‐532‐5p	0.02	0.21	0.02	1.48	Up
hsa‐miR‐1296‐5p	0.03	0.22	0.03	1.44	Up
hsa‐miR‐3184‐3p	0.009	0.21	0.008	1.42	Up
hsa‐miR‐423‐3p	0.01	0.21	0.01	1.43	Up
hsa‐miR‐199a‐3p	0.03	0.22	0.01	2.01	Up

FDR, false discovery rate.

All eight differentially expressed miRNAs were up‐regulated in cachectic cases with a fold change of ≥1.4 at P < 0.05. Permutation test was carried out (n = 10 000) for these seven miRNAs to rule out observation by chance. The permuted P‐value was significant for all the eight differentially expressed miRNAs. FDR for all eight differentially expressed miRNAs were also represented.