Table 1.

Potential pharmacological approaches targeting immunological mechanisms in ischemia/reperfusion injury.

Target	Mechanism	Drug
TLR	Antagonists of TLR	TAK242 TJ-M2010-2
NF-κB	Decreased degradation of NF-κB inhibitory protein IκBα	Proteasome inhibitor (Lactacystin, PS519)
Dendritic cells	A2AR agonists	ATL313 ATL146e
Treg cells	Expansion of Treg cells	Sphingosine N,N-dimethylsphingosine Histone/protein deacetylases inhibitors A2aR agonists