Figure 1.

Genomic decision tree to differentiate vasodilator-responsive pulmonary arterial hypertension (VR-PAH) from vasodilator-nonresponsive pulmonary arterial hypertension (VN-PAH). The figure shows an example of a decision tree based on the primary gene RHOQ with a secondary gene, TPD52. RHOQ encodes a cytoskeletal protein involved in insulin-mediated signaling, TPD52 encodes a protein in vesicle-mediated transfer, and DSG2 is a desmosomal cadherin involved in Wnt/B-catenin signaling. Numbers shown within the tree are for the performance of the tree in the test cohort, and in the upper right is the performance in the validation cohort. This genomic decision tree correctly identified five of five vasodilator-responsive patients in the validation cohort. Adapted by permission from Reference 19.