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. Author manuscript; available in PMC: 2017 Oct 7.
Published in final edited form as: Org Lett. 2017 Mar 24;19(7):1910–1913. doi: 10.1021/acs.orglett.7b00683

Figure 2.

Figure 2

Reduction of secondary amides with varying C-substituents. (a) Conditions unless otherwise stated: NiCl2(dme) (10 mol %), substrate (1.0 equiv, 0.2 mmol), PhSiH3 (2.0 equiv), and toluene (1.0 M) at 115 °C for 24 h in a sealed vial. Yields shown reflect the average of two isolation experiments. (b) PhSiH3 (4.0 equiv) was used. (c) Yields determined by 1H NMR analysis using hexamethylbenzene as an internal standard.