Table 3.
Summary of the associations between genetic alterations in mPTC and clinico-pathologic features.
| Study | Age | Gender | LNM c | Multifocality | Extrathyroidal Extension | Advanced Disease Stage d | Size |
|---|---|---|---|---|---|---|---|
| RET/PTC rearrangements | |||||||
| Corvi et al. 2001[20] | No | --- | --- | --- | --- | --- | No |
| Bastos et al. 2015 [24] | --- | --- | No | --- | No | No | --- |
| Ras mutation | |||||||
| Bastos et al. 2015 (NRAS) [24] | --- | --- | No | --- | No | No | --- |
| TERT promoter mutation | |||||||
| de Biase et al. 2015 [25] | No b | No | No | No | --- | No | No c |
| BRAF V600E mutation | |||||||
| Kim et al. 2005 [31] | No a | No | No | No | No | No | --- |
| Lupi et al. 2007 [40] | No a | No | No | No | Yes | Yes | --- |
| Rodolico et al. 2007 [41] | Yes b | No | Yes | No | No | --- | No g |
| Ugolini et al. 2007 [36] h | No | No | --- | --- | --- | --- | No |
| Frasca et al. 2008 [42] | --- | --- | No | No | Yes | Yes | --- |
| Min et al. 2008 [44] | --- | --- | No | --- | --- | --- | --- |
| Kwak et al. 2009 [46] | No b | No | No | No | --- | No | # |
| Lee et al. 2009 [47] | No b | No | Yes | --- | Yes | Yes | --- |
| Basolo et al. 2010 [49] | Yes a | No | Yes | No | Yes | Yes | --- |
| Lin et al. 2010 [50] | No b | No | Yes | Yes | Yes | Yes | --- |
| Kurtulmus al 2012 [51] | --- | --- | Yes | No | No | --- | --- |
| Lee et al. 2012 [37] | No b | No | No | No | No | --- | No f |
| Zhou et al. 2012 [52] | --- | --- | --- | --- | --- | --- | --- |
| Lim et al. 2013 [57] | --- | --- | Yes | --- | Yes | Yes | Yes e |
| Choi et al. 2013 [58] | No a | No | No | No | No | No | --- |
| Mussazhanova et al. 2013 [35] | No b | No | No | --- | No | --- | No e |
| Rossi et al. 2013 [59] | --- | --- | Yes | --- | No | --- | --- |
| Virk et al. 2013 [33] | No a | No | Yes | No | Yes | --- | No f |
| Zheng et al. 2013 [60] | No a | Yes | Yes | No | Yes | Yes | Yes f |
| Chung YJ et al. 2013 [28] | --- | --- | No | --- | --- | --- | --- |
| Chung SY et al. 2013 [61] | --- | --- | No | --- | --- | --- | --- |
| Yang et al. 2014 [64] | --- | --- | Yes | --- | --- | --- | --- |
| Walczyk et al. 2014 [29] | No a | No | No | --- | --- | --- | No e |
| Tallini et al. 2015 [30] | Yes b | No | Yes | No | Yes | Yes | Yes f |
| Yu et al. 2015 [66] | --- | --- | No | --- | --- | --- | --- |
| Bastos et al. 2015 [24] | --- | --- | No | --- | No | No | --- |
| de Biase et al. 2015 [25] | No b | No | Yes | No | --- | Yes | Yes e |
| Total BRAF studies | 3/16 | 1/16 | 12/25 | 1/14 | 9/17 | 9/13 | 4/10 |
Only univariate analysis are shown. No – without statistically significant association; Yes – with statistically significant association; # data not clear; a cut off < or > 45 years old; b mean age; c either for central or lateral LNM; d classified by TNM/AJCC staging system; e cut off mean size; f cut off < or > 5mm; g maximal diameter; h Only occult mPTC.