Table 3.
Prognostic factors for local failure (LF)
| Factor | No. of patients | 5-year LF (%) | p |
|---|---|---|---|
| Age at diagnosis | |||
| <4 years | 123 | 9.8 | 0.92 |
| ≥4 years | 123 | 9.5 | |
| Site of primary tumor | |||
| Abdominal | 232 | 9.7 | 0.77 |
| Non-abdominal | 14 | 12.5 | |
| MYCN | |||
| Non-amplified | 131 | 8.2 | 0.09 |
| Amplified | 96 | 14.0 | |
| LDH | |||
| <1500 | 113 | 6.7 | 0.06 |
| ≥1500 | 65 | 14.4 | |
| Ferritin | |||
| <142 | 36 | 6.0 | 0.32 |
| ≥142 | 88 | 11.9 | |
| Shimada histopathology | |||
| Favorable | 11 | 0.0 | 0.27 |
| Unfavorable | 173 | 12.6 | |
| Skeletal metastases | |||
| Present | 195 | 7.0 | 0.003 |
| Absent | 51 | 20.1 | |
| No. of surgeries to achieve GTR | |||
| 1 | 212 | 8.3 | 0.01 |
| >1 | 29 | 22.4 | |
| Time from chemotherapy to RT | |||
| <7.8 months | 121 | 11.2 | 0.60 |
| ≥7.8 months | 125 | 8.5 | |
| Response to chemotherapy | |||
| CR/VGPR | 135 | 11.5 | 0.29 |
| PR/MR/PD | 111 | 7.0 | |
| Stem cell transplant | |||
| Yes | 75 | 6.7 | 0.29 |
| No | 171 | 11.5 | |
Abbreviations: LF = local failure; GTR = gross total resection; RT = radiation therapy; CR/VGPR = complete remission/very good partial remission; PR/MR/PD = partial remission/mixed response/progressive disease