Table 1.

Study characteristics.

Study	Country	Year of publication	Population	Number of patient	Number of polyp	Mean age (year)	Male sex	Size of polyp (Mean)	Type of polyp	Location of polyp	Comparision	Concentration of epinephrine solution	Polypectomy method	Outcome variable	Pathology	Post polypectomy bleeding (%)	Anticoaulant used or coagulopathy	Blood tranfusion	Modified Jadad score
Lee SH.	South korea	2007	Multicenter	486	561	Epinephrine group: 51.6 ± 11.4, Controlled group: 56.8 ± 11.3	379	Epinephrine group: 14.5 ± 5.7 mm, Controlled group:15.0 ± 6.8 mm.	Pedunculated: 128 Semipeduncul ated: 200 Sessile: 150 Superficial elevated type: 83	Right colon (include transverse colon):99 Left colon:257 Both: 130	Epinephrine versus Controlled (normal saline solution)	0.01% (Total volume 2–25 ml)	Bipolar cauterization, blended current (30–40 Watts)	-Early bleeding (within 12 h) - Late bleeding (12 h.-30 days)	Nonneoplastic: 51 Dysplasia:362 High grade Dysplasia:95 Cancer: 53	8%	Excluded	–	9
Hsieh Yh.	Taiwan	2001	Single center	122	151	Epinephrine group 62.9 (59.8–62.1), Controlled group: 64.9 (62.1–67.8)	80	Epinephrine group: 8 (8–13) mm., Controlled group: 8 (8–11) mm.	Sessile	Ascending: 10 Transverse: 4 Descending:7 Sigmoid: 50 Rectum 16	Epinephrine versus Controlled	0.01% (Total volume 2–10 ml)	Coagulation current (25–30 Watts)	-Early bleeding (within 24 h) -Late bleeding (>24 h.-30 days) -Perforation -Mortality	Nonneoplastic: 12 Tubular: 59 Tubulovillus:13 Villus: 2 Carcinoid: 2	6.0%	Excluded	2	6
Dobrowolski S.	Poland	2004	Single center	69	100	64.6 ± 10.5	44	Epinephrine group: 16.3 ± 5.4 mm, Controlled group:16.1 ± 5.9 mm.	Pedunculated: 80 Sessile: 20	Ascending: 6 Transverse: 10 Descending: 13 Sigmoid: 51 Rectum 20	Epinephrine versus Controlled	0.01% (Total volume 2–10 ml)	Endocut, effect 3 (output limit 120 W) and Soft coagulation (output limit 60 W)	-Early bleeding (within 24 h) -Late bleeding (>24 h.-30 days)	Nonneoplastic: 6 Tubular: 23 Tubulovillus:51 Adenocarcinim a: 20	9%	Excluded	2	7
Paspatis GA.	Greece	2006	Multicenter	159	159	Epinephrine group: 64.5 ± 11, Epinephrine + snare group: 61.7 ± 13.8	84	Epinephrine group: 26.3 ± 8.1 mm, Epinephrine + snare group: 27.1 ± 8.9 mm.	Pedunculated	Right colon: 13 Left colon:130 Rectum: 16	Epinephrine versus Epinephrine and Detachable snare	0.01% (Total volume 2–3 ml)	Endocut mode (72 W)	-Early bleeding (within 24 h) -Late bleeding (>24 h.-30 days) - Blood transfusion - Operation need	–	6%	Excluded	1	7
Kouklakis G.	Greece	2009	Single center	64	64	Epinephrine group: 58.8 ± 11.2, Endoloop + clip group: 57.9 ± 9.7	35	Epinephrine group: 2.7 ± 1.1 cm. Endoloop + clip group: 2.56 ± 1.2 cm.	Pedunculated	Ascending: 3 Transverse: 4 Descending:8 Sigmoid: 35 Rectum 14	Epinephrine versus Endoloop and hemoclip	0.01% (Total volume 2–5 ml)	Monopolar coagulation in endocut function (72 W)	-Early bleeding (within 24 h) -Late bleeding (>24 h.-30 days) - Blood transfusion	Neoplastic:5 Severe dysplasis: 13 Mild-moderate dysplasia:46	8%	Excluded	3	8
Di Giorgio P.	Italy	2004	Single center	488	488	Epinephrine group: 63 ± 8.9, Controlled group: 62 ± 9.0, Snare group: 64 ± 9.2	267	Epinephrine group: 24.72 ± 5.31 mm, Controlled group: 21.55 ± 4.77 mm, Snare group: 22.15 ± 5.92 mm.	Pedunculated	Right colon: 88 Left colon: 125 Rectosigmoid: 275	Epinephrine versus Controlled versus Detachtable snare	0.01% (Total volume 2 ml)	Bipolar cauterization, blended current (75 Watts)	-Early bleeding (within 24 h) -Late bleeding (>24 h.-30 days)	–	4%	Excluded	–	7