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. Author manuscript; available in PMC: 2018 Apr 25.
Published in final edited form as: ACS Nano. 2017 Mar 28;11(4):4315–4327. doi: 10.1021/acsnano.7b01530

Figure 5.

Figure 5

Toxicity evaluations of UiO-66 conjugates. (a) Growth chart of mice post-treatment of UiO-66/Py–PGA-PEG (dose: 10 mg/kg) and normal saline. (b) Healthy female Balb/c mice with the intravenous injection of UiO-66/Py–PGA-PEG were sacrificed on 1, 7, and 30 days p.i. for blood collection. Untreated healthy mice were used as the control. Alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels of Balb/c mice injected with saline (control) are similar to those injected with UiO-66/Py–PGA-PEG (dose: 10 mg/kg) at different time points (n = 5). (c) H&E stained major organ slides collected from healthy Balb/c mice and UiO-66/Py–PGA-PEG-injected mice (dose: 10 mg/kg) on day 30 post injection (n = 5). Scale bar: 100 μm.