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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mucosal Immunol. 2017 Mar 1;10(4):1069–1081. doi: 10.1038/mi.2017.15

Figure 4. Preferential accumulation of IL-22+ macrophages within granulomas of latent TB.

Figure 4

NHPs were aerosol infected with Mtb CDC1551 and lungs were harvested from NHPs with (a) latent and (b) acute TB. FFPE lung sections were prepared and stained for (left) H&E or immunofluorescence with antibodies specific for (middle) E-cadherin (red) and IL-22R (green), or (right) macrophage (green) and IL-22R (red). All sections were counterstained with DAPI (blue). White arrows indicate co-localization of IL-22R with macrophage or epithelial markers. Original magnification for (left) H& E panel is 100×, (middle & right) immunofluorescence panels 200×. (c) Induction of IL-22RA1 and IL-10RA was measured by real-time PCR and fold induction in either latently or actively infected NHP lungs over levels expressed in control lungs is shown. n = 4-6. Error bars represent means ± s.e.m. ND, not detected.