Comparison 1. Medication versus placebo (regardless of timing).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Intraocular pressure (IOP) increase of ≥ 5 mmHg within 2 hours after laser trabeculoplasty (LTP)	2		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.1 Alpha‐2 agonists vs placebo	2		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 IOP increase of ≥ 10 mmHg within 2 hours after LTP	4	446	Risk Ratio (M‐H, Random, 95% CI)	0.05 [0.01, 0.20]
2.1 Acetazolamide vs placebo	1	100	Risk Ratio (M‐H, Random, 95% CI)	0.03 [0.00, 0.52]
2.2 Alpha‐2 agonists vs placebo	3	346	Risk Ratio (M‐H, Random, 95% CI)	0.06 [0.01, 0.27]
3 Mean change in IOP from pre‐LTP to measurements taken within 2 hours after LTP	4		Mean Difference (Random, 95% CI)	Subtotals only
3.1 Apraclonidine vs placebo (mmHg)	4	151	Mean Difference (Random, 95% CI)	‐7.43 [‐10.60, ‐4.27]
4 IOP increase of ≥ 5 mmHg two to 24 hours after LTP	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Alpha‐2 agonists vs placebo	5	634	Risk Ratio (M‐H, Random, 95% CI)	0.17 [0.09, 0.31]
5 IOP elevation of ≥ 10 mmHg two to 24 hours after LTP	9	817	Risk Ratio (M‐H, Random, 95% CI)	0.22 [0.11, 0.42]
5.1 Alpha‐2 agonists vs placebo	7	727	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.07, 0.50]
5.2 Dorzolamide vs placebo	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.27 [0.01, 5.22]
5.3 Pilocarpine vs no treatment	1	50	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.07, 0.71]
6 Mean change in IOP from pre‐LTP to measurements two to 24 hours after LTP	4		Mean Difference (Random, 95% CI)	Subtotals only
6.1 Apraclonidine vs placebo (mmHg)	4	151	Mean Difference (Random, 95% CI)	‐5.32 [‐7.37, ‐3.28]