Comparison 3. Medication versus medication: apraclonidine versus pilocarpine (regardless of timing).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean change in intraocular pressure (IOP) from pre‐laser trabeculoplasty (LTP) to measurements taken within 2 hours after LTP (mmHg)	2	277	Mean Difference (Random, 95% CI)	0.61 [‐0.44, 1.66]
2 IOP increase of ≥ 5 mmHg two to 24 hours after LTP	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3 IOP increase of ≥ 10 mmHg two to 24 hours after LTP	2	390	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.14, 5.63]
4 Mean change in IOP from pre‐LTP to measurements taken two to 24 hours after LTP (mmHg)	2		Mean Difference (Fixed, 95% CI)	Subtotals only