Comparison 4. Timing comparison: medication before versus medication after.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Intraocular pressure (IOP) increase of ≥ 5 mmHg two to 24 hours after laser trabeculoplasty (LTP)	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Alpha‐2 agonists	4	319	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.25, 2.63]
2 IOP increase of ≥ 10 mmHg two to 24 hours after LTP	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Alpha‐2 agonists	4	319	Risk Ratio (M‐H, Random, 95% CI)	1.55 [0.19, 12.43]
3 Mean change in IOP from pre‐LTP to measurements taken more than 2 hours but within 24 hours after LTP (mmHg)	3		Mean Difference (Random, 95% CI)	Subtotals only
3.1 Alpha‐2 agonists (mmHg)	3	198	Mean Difference (Random, 95% CI)	‐1.07 [‐2.51, 0.37]