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. 2017 Jun 20;5:46. doi: 10.1186/s40425-017-0249-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Immunohistochemical analysis of brain lesion. a Staining with CK22 monoclonal anti-cytokeratin antibody cocktail. b Staining with the astroglial marker anti-GFAP (glial fibrillary acidic protein). Scale bar: 20 μm. c CD45 (leukocyte antigen) staining for the detection of immune cells demonstrates perivascular infiltrates. Scale bar: 50 μm. d Very few CD20-positive B cells are detected. Scale bar: 20 μm. e The perivascular infiltrate are predominantly PD-1 positive T cells. Scale bar: 20 μm. f CD68 staining of macrophages highlights resorptive changes. Scale bar: 50 μm. (g, h) The perivascular T cell infiltrates are mainly CD8 T cells. Scale bar: 20 μm. i Only little PD-L1 staining was detected. Scale bar: 20 μm