Table 4.
Multivariable analysis with multiple imputation of clinical variables, S100, and neuron-specific enolase
| 95% CI | |||||
|---|---|---|---|---|---|
| Model S100 + NSE + clinical analysis | Effect | Odds ratio | Lower | Upper | p Value |
| Intercept | −6.480 | 0.00 | 0.01 | <0.001 | |
| S100 at 24 h | 1.012 | 2.751 | 0.49 | 15.33 | 0.25 |
| S100 at 48 h | −1.808 | 0.164 | 0.00 | 6.89 | 0.34 |
| S100 at 72 h | 2.284 | 9.820 | 0.24 | 401.61 | 0.23 |
| NSE at 24 h | −0.041 | 0.960 | 0.93 | 0.98 | <0.001 |
| NSE at 48 h | 0.065 | 1.068 | 1.04 | 1.10 | <0.001 |
| NSE at 72 h | 0.026 | 1.026 | 1.00 | 1.05 | 0.02 |
| Target temperature | 0.187 | 1.206 | 0.76 | 1.91 | 0.43 |
| Age | 0.091 | 1.095 | 1.07 | 1.12 | <0.001 |
| Time CA to ROSC | 0.009 | 1.010 | 1.00 | 1.02 | 0.17 |
| Lactate level on admission | 0.003 | 1.003 | 0.94 | 1.07 | 0.93 |
| Sex | −0.400 | 0.671 | 0.38 | 1.20 | 0.18 |
| Bystander CPR performed | −0.706 | 0.494 | 0.29 | 0.83 | 0.01 |
| VT/VF versus PEA/asystole | −1.062 | 0.346 | 0.17 | 0.72 | <0.001 |
| ROSC after bystander defibrillation | −0.926 | 0.396 | 0.07 | 2.11 | 0.28 |
| Shock on admission | 0.356 | 1.428 | 0.68 | 2.99 | 0.34 |
Abbreviations: CA Cardiac arrest, CPR Cardiopulmonary resuscitation, NSE Neuron-specific enolase, PEA Pulseless electrical activity, ROSC Return of spontaneous circulation, VF Ventricular fibrillation, VT Ventricular tachycardia