Table 2.
Rotational thromboelastometry and platelet function analysis closure time prior to (T0), and at 5 (T5), 60 (T60) and 120 (T120) minutes after administration of mannitol and hypertonic saline (HTS)
| Variable | Time point | Osmotherapeutic solution and sample size | |||
|---|---|---|---|---|---|
| Mannitol | Sample size | HTS | Sample size | ||
| CtPFA
(RI: 42-90s) |
T0 | 76 (72-86) | 15 | 90 (75-102) | 13 |
| T5 | 96 (79-127) | 15 | 96 (77-138) | 13 | |
| T60 | 85 (76-96) | 11 | 98 (70-113) | 12 | |
| T120 | 79 (75-83) | 8 | 78 (71-118) | 11 | |
| EXTEM® CT (RI: 20-85 s) |
T0 | 42 (37-50) | 15 | 42 (35-54) | 15 |
| T5 | 41 (32-45) | 15 | 38 (35-50) | 15 | |
| T60 | 38 (36-49) | 11 | 40 (34-45) | 12 | |
| T120 | 43 (29-46) | 9 | 41 (36-49) | 11 | |
| EXTEM® CFT (RI: 55-374 s) |
T0 | 84 (59-129) | 14 | 93 (86-111) | 15 |
| T5 | 114 (74-145) | 14 | 115 (102-124) | 14 | |
| T60 | 97 (68-105) | 10 | 115 (99-190) | 12 | |
| T120 | 98 (77-125) | 8 | 108 (93-147) | 11 | |
| EXTEM® A10 (RI: 17-69 mm) |
T0 | 58 (46-62) | 15 | 54 (49-61) | 15 |
| T5 | 56 (46-58) | 15 | 51 (39-61) | 14 | |
| T60 | 57 (53-67) | 11 | 54 (53-67) | 12 | |
| T120 | 60 (52-63) | 9 | 55 (44-56) | 11 | |
| EXTEM® α-angle (RI: 57-86°) |
T0 | 73 (61-81) | 14 | 72 (69-75) | 15 |
| T5 | 76 (65-71) | 14 | 67 (64-71) | 14 | |
| T60 | 72 (69-79) | 10 | 69 (64-77) | 12 | |
| T120 | 69 (65-81) | 8 | 70 (65-75) | 11 | |
| EXTEM® MCF (RI: 29-75 mm) |
T0 | 68 (52-69) | 15 | 66 (59-69) | 15 |
| T5 | 65 (51-67)* | 15 | 62 (51-67) | 14 | |
| T60 | 67 (64-74) | 11 | 63 (50-67) | 12 | |
| T120 | 68 (61-71) | 9 | 63 (58-65) | 11 | |
| FIBTEM® CT (RI: 18-72 s) |
T0 | 38 (31-44) | 15 | 42 (36-46) | 14 |
| T5 | 36 (32-44) | 15 | 33 (32-39)* | 14 | |
| T60 | 39 (33-50) | 11 | 35 (30-36)* | 11 | |
| T120 | 40 (32-44) | 9 | 35 (36-42)* | 10 | |
| FIBTEM® A10 (RI: 2-17 mm) |
T0 | 12 (10-21) | 15 | 11 (6-15) | 14 |
| T5 | 11 (10-17) | 15 | 10 (7-13) | 14 | |
| T60 | 14 (10-21) | 11 | 10 (9-15) | 11 | |
| T120 | 16 (11-17) | 9 | 11 (8-15) | 10 | |
| FIBTEM® α-angle (RI: 61-88°) |
T0 | 75 (65-79) | 13 | 67 (65-74) | 10 |
| T5 | 75 (67-81) | 11 | 72 (70-75) | 10 | |
| T60 | 77 (74-79) | 8 | 67 (62-76) | 8 | |
| T120 | 76 (64-78) | 8 | 72 (61-77) | 6 | |
| FIBTEM® MCF (RI: 3-17 mm) |
T0 | 14 (9-20) | 15 | 12 (7-16) | 14 |
| T5 | 13 (9-19)* | 15 | 11 (8-13) | 13 | |
| T60 | 14 (9-18)* | 11 | 10 (9-15) | 11 | |
| T120 | 15 (13-18) | 9 | 12 (9-15) | 10 | |
Ct PFA platelet closure time, CT clotting time, CFT clot formation time, A10 clot firmness amplitude 10 min after CT, MCF maximal clot firmness; variables are shown as median (interquartile range), RI institutional reference intervals; bold font, median value outside of the RI; *, significant different to T0 (P < 0.05)