Table 3.

Rotational thromboelastometry and platelet function analysis closure time (Ct_PFA) prior to (T₀), and at 5 (T₅), 60 (T₆₀) and 120 (T₁₂₀) minutes after administration of mannitol and hypertonic saline (HTS) shown as the percentage of values relative to T₀

		Osmotherapeutic solution
Variable	Time point	Mannitol (% from baseline)	HTS (% from baseline)	P value
CtPFA	T5	130 (103-171)	116 (89-151)	0.31
	T60	109 (95-126)	112 (89-149)	1.00
	T120	100 (93-109)	91 (87-107)	0.32
EXTEM® CT	T5	92 (51-113)	91 (60-239)	0.35
	T60	107 (70-128)	95 (60-1299	0.21
	T120	113 (40-159)	98 (48-143)	0.65
EXTEM® CFT	T5	115 (73-246)	118 (84-216)	0.98
	T60	111 (62-194)	113 (83-359)	0.97
	T120	115 (80-182)	109 (70-162)	0.62
EXTEM® A10	T5	97 (61-122)	98 (16-112)	0.44
	T60	103 (86-2014)	102 (88-260)	0.68
	T120	97 (92-127)	100 (84-215)	0.37
EXTEM® α-angle	T5	98 (65-273)	96 (20-104)	0.48
	T60	99 (71-119)	98 (71-109)	0.97
	T120	100 (71-113)	100 (93-111)	0.87
EXTEM® MCF	T5	97 (70-300)	97 (28-104)	0.86
	T60	100 (91-469)	98 (46-106)	0.12
	T120	101 (90-446)	97 (89-111)	0.22
FIBTEM® CT	T5	100 (70-138)	86 (56-108)	0.01
	T60	111 (72-163)	81 (55-110)	0.01
	T120	94 (75-142)	85 (25-126)	0.11
FIBTEM® A10	T5	85 (62-167)	103 (15-167)	0.05
	T60	114 (82-146)	100 (33-300)	0.76
	T120	106 (81-135)	100 (64-200)	0.76
FIBTEM® α-angle	T5	101 (80-109)	106 (97-119)	0.09
	T60	99 (92-107)	101 (22 (124)	0.60
	T120	100 (93-104)	96 (83-112)	0.56
FIBTEM® MCF	T5	89 (58-188)	100 (19-171)	0.11
	T60	88 (59-104)	100 (14-143)	0.07
	T120	88 (62-188)	104 (19-143)	0.60

Ct _PFA platelet closure time, CT clotting time, CFT clot formation time, A10 amplitude after 10 min, MCF maximal clot firmness; values shown as median (interquartile range) percentage of measurements relative to T_{0; bold font, P <0.05}