Table 1.
Comparison of the predicted upstream regulatory pathways in ESCC
| GSE77861 | GSE17351 | GSE33810 | GSE20347 | ||||||||
| Gene | z-score | -log(p) | Gene | z-score | -log(p) | Gene | z-score | -log(p) | Gene | z-score | -log(p) |
| NFE2L2 | 3.8 | 7.5 | NUPR1 | 4.7 | 10.1 | mir-8 | 2.6 | 1.2 | RABL6 | 5.8 | 26.7 |
| MEK | 2.7 | 1.2 | CLDN7 | 3.9 | 7.9 | let-7 | 2.6 | 0.3 | FOXM1 | 4.4 | 14.2 |
| LDL | 2.8 | 0.5 | MYOCD | 3.8 | 6.0 | LYN | 2.4 | 0.6 | IgG complex | 3.7 | 21.9 |
| CTNNB1 | 2.6 | 1.6 | NR3C1 | 3.7 | 4.2 | IL10RA | 2.3 | 1.0 | MITF | 3.5 | 15.8 |
| RABL6 | 2.5 | 2.1 | IRGM1 | 3.5 | 7.0 | TRIM24 | 2.4 | 0.1 | FOXO1 | 3.4 | 11.3 |
| FOXM1 | 2.4 | 1.2 | BNIP3L | 3.4 | 8.2 | miR-1-3p | 2.2 | 0.8 | RARA | 3.3 | 16.2 |
| CBX5 | 2.3 | 2.4 | RBL2 | 3.2 | 4.8 | IFI16 | 2.2 | 0.4 | TLR7 | 3.3 | 4.2 |
| ANGPT2 | 2.3 | 2.3 | TP53 | 3.2 | 21.1 | ZBTB16 | 2.2 | 2.0 | PRL | 3.3 | 8.1 |
| PLIN5 | 2.2 | 2.2 | IL1RN | 3.1 | 4.3 | miR-10 | 2.2 | 0.4 | IFNL1 | 3.2 | 10.0 |
| ANXA7 | 2.2 | 2.4 | SRF | 3.0 | 5.7 | CDKN2A | 2.1 | 0.1 | TGFB1 | 3.2 | 46.3 |
| TP53 | −3.1 | 18.4 | CSF2 | −5.6 | 9.3 | ERBB2 | −3.2 | 8.2 | TP53 | −5.3 | 38.7 |
| IL13 | −3.0 | 0.7 | RABL6 | −4.1 | 8.9 | SHH | −3.1 | 7.8 | NUPR1 | −4.4 | 19.5 |
| CDKN2A | −3.0 | 2.6 | SPP1 | −4.1 | 5.3 | IGFBP2 | −3.1 | 7.5 | SPDEF | −4.0 | 8.7 |
| CD28 | −2.8 | 2.0 | EGFR | −3.8 | 14.0 | TGFB3 | −2.9 | 7.5 | KDM5B | −3.4 | 12.6 |
| EHF | −2.5 | 2.3 | ERK1/2 | −3.8 | 9.2 | ERG | −2.9 | 7.0 | HSF1 | −3.3 | 6.7 |
| CLDN7 | −2.4 | 3.9 | EGF | −3.7 | 9.9 | CCTNB1 | −2.7 | 7.1 | CDKN1A | −3.3 | 9.5 |
| let-7 | −2.2 | 0.5 | HGF | −3.6 | 17.1 | CREB | −2.6 | 1.7 | CLDN7 | −3.1 | 6.7 |
| ESRRA | −2.2 | 1.4 | TNF | −3.4 | 3.9 | WNT1 | −2.5 | 0.6 | BTK | −2.9 | 5.0 |
| TCF3 | −2.0 | 0 | E2F1 | −3.4 | 7.9 | CCND1 | −2.5 | 2.9 | WISP2 | −2.9 | 8.6 |
| FGFR1 | −2.0 | 0.8 | FN1 | −3.4 | 4.7 | ERG2 | −2.5 | 0.9 | E2F6 | −2.8 | 4.3 |
| GSE29001 | GSE33426 | GSE45670 | GSE23400 | ||||||||
| Gene | z-score | -log(p) | Gene | z-score | -log(p) | Gene | z-score | -log(p) | Gene | z-score | -log(p) |
| RABL6 | 5.8 | 25.2 | TGFB1 | 7.7 | 42.9 | TNF | 5.3 | 24.0 | CSF2 | 5.0 | 14.4 |
| HGF | 5.7 | 39.5 | TNF | 7.2 | 15.1 | ERBB2 | 4.9 | 21.3 | RABL6 | 4.7 | 19.7 |
| VEGF | 5.3 | 32.7 | VEGF | 7.0 | 15.0 | CSF | 4.2 | 4.8 | VEGF | 4.4 | 32.3 |
| FOXM1 | 5.0 | 19.4 | HGF | 6.9 | 22.0 | EGFR | 3.9 | 13.6 | HGF | 4.2 | 38.8 |
| CSF2 | 5.0 | 30.7 | ESR1 | 6.9 | 42.0 | IFNL1 | 3.8 | 5.8 | FOXM1 | 4.0 | 16.0 |
| E2F1 | 4.6 | 28.1 | EGF | 6.5 | 12.0 | IFNG | 3.7 | 21.3 | ESR1 | 3.9 | 31.1 |
| TBX2 | 4.4 | 13.0 | CSF2 | 6.5 | 14.0 | CCND1 | 3.7 | 18.5 | ERBB2 | 3.7 | 56.4 |
| E2F group | 4.2 | 15.8 | CTNNB1 | 6.3 | 13.0 | IL1A | 3.6 | 15.5 | FN1 | 3.7 | 7.5 |
| IFNA1 | 3.7 | 6.4 | SMARCA4 | 6.2 | 11.0 | RABL6 | 3.6 | 5.1 | TBX2 | 3.6 | 12.2 |
| IFNL1 | 3.6 | 13.0 | IFNG | 5.9 | 15.0 | OSM | 3.5 | 15.6 | EGF | 3.4 | 32.6 |
| NUPR1 | −6.2 | 15.6 | let-7 | −6.0 | 19.0 | GATA4 | −4.8 | 11.6 | TP53 | −5.2 | 53.0 |
| let-7 | −5.0 | 17.0 | CD3 | −5.1 | 15.0 | IL10RA | −4.3 | 7.4 | CDKN2A | −4.3 | 10.5 |
| KDM5B | −4.5 | 10.7 | SPDEF | −4.2 | 8.0 | MYOCD | −3.9 | 11.2 | let-7 | −3.9 | 16.0 |
| IRGM | −4.5 | 14.8 | KDM5B | −4.1 | 7.5 | IL1RN | −3.6 | 8.1 | RB1 | −3.8 | 17.7 |
| TP53 | −4.2 | 54.2 | IRGM1 | −4.0 | 9.0 | IRGM1 | −3.5 | 6.5 | NR3C1 | −3.5 | 7.9 |
| SPDEF | −4.1 | 10.2 | TRIM24 | −4.9 | 4.0 | HAND2 | −3.3 | 5.7 | SPDEF | −3.4 | 8.5 |
| RBL2 | −4.0 | 13.7 | RB1 | −3.9 | 14.0 | SRF | −3.3 | 11.1 | PPARG | −3.3 | 13.0 |
| BNIP3L | −4.0 | 17.3 | RBL2 | −3.9 | 7.2 | ACKR2 | −3.2 | 5.3 | let-7a-5p | −3.3 | 4.3 |
| CDKN2A | −3.9 | 7.3 | IL1RN | −3.8 | 2.2 | PTEN | −3.2 | 5.0 | IRGM1 | −3.2 | 7.2 |
| TRIM24 | −3.8 | 18.2 | CD28 | −3.6 | 8.2 | POU5F1 | −3.0 | 2.4 | CR1L | −3.1 | 8.9 |
The upstream regulatory pathways represented more than one study in the meta-analysis indicated in bold