Table 1.

A summary of in vitro studies on the role of EGCG on AD prevention

Cell lines	Drug and dosage	Results	References
MC65	EGCG 20 μM	EGCG reduced the Aβ levels by enhancing endogenous APP proteolysis and decreased nuclear translocation of c-Abl.	[20]
EOC 13.31	EGCG 5 to 20 μM	EGCG suppressed the expression of Aβ-induced TNFα, IL-1β, IL-6, and iNOS, and restored the levels of intracellular antioxidants Nrf2 and HO-1.	[23]
SweAPP N2a	GTE	EGCG reduced the Aβ generation and activated nonamyloidogenic processing of APP by promoting its α-secretase cleavage.	[24]
Div8	EGCG 12.5–50 μM	EGCG induced an increase in the key autophagy adaptor proteins NDP52 and p62.	[27]
M146 L, CHO	EGCG 16–32 μmol/L	EGCG reduced the accumulation of β-amyloid (Aβ).	[28]
N2a/APP695	EGCG (5–100 μM)	EGCG suppressed the production of Aβ and reduced inflammation, oxidative stress and cell apoptosis.	[29]