Table 1.
Baseline characteristics of patients with transcatheter aortic valve implantation with and without CKD
| Predictors | Without CKD | CKD Stage 1 | CKD Stage 2 | CKD Stage 3 | CKD Stage 4 | CKD Stage 5 | P Value |
|---|---|---|---|---|---|---|---|
| Patients, n (% of all) | 17,527 | 193 | 1971 | 6755 | 1405 | 865 | <0.001 |
| Age, yr, mean±SD | 80.9±6.1 | 80.5±5.7 | 81.1±5.8 | 81.5±5.8 | 81.7±5.9 | 76.4±7.3 | <0.001 |
| Women, n (%) | 10,114 (57.7) | 105 (54.4) | 1007 (51.1) | 3688 (54.6) | 902 (64.2) | 321 (37.1) | <0.001 |
| EuroSCORE, mean (%)±SD. | 20.4±12.2 | 19.4±11.0 | 22.0±12.8 | 23.3±13.7 | 36.1±16.5 | 30.2±17.3 | <0.001 |
| Isolated aortic valve stenosis, n (%) | 12,148 (69.3) | 151 (78.2) | 1328 (67.4) | 4337 (64.2) | 886 (63.1) | 575 (66.5) | <0.001 |
| Combined aortic valve disease, n (%) | 4543 (25.9) | 37 (19.2) | 524 (26.6) | 1993 (29.5) | 432 (30.8) | 236 (27.3) | <0.001 |
| CAD, n (%) | 7764 (44.3) | 93 (48.2) | 943 (47.8) | 3460 (51.2) | 708 (50.4) | 440 (50.9) | <0.001 |
| PAD, n (%) | 1792 (10.2) | 23 (11.9) | 270 (13.7) | 955 (14.1) | 203 (14.5) | 210 (24.3) | <0.001 |
| Carotid disease, n (%) | 1035 (5.9) | 13 (6.7) | 128 (6.5) | 447 (6.6) | 95 (6.8) | 49 (5.7) | 0.29 |
| NYHA 2 | 1450 (8.3) | 13 (6.7) | 193 (9.8) | 527 (7.8) | 106 (7.5) | 64 (7.4) | 0.07 |
| NYHA 3 or 4 | 6312 (36.0) | 80 (41.5) | 887 (45.0) | 3220 (47.7) | 726 (51.7) | 427 (49.4) | <0.001 |
| Previous CABG, n (%) | 2027 (11.6) | 31 (16.1) | 291 (14.8) | 1008 (14.9) | 190 (13.5) | 129 (14.9) | <0.001 |
| Previous cardiac surgery, n (%) | 2980 (17.0) | 34 (17.6) | 386 (19.6) | 1400 (20.7) | 269 (19.2) | 190 (22.0) | <0.001 |
| Previous myocardial infarction, n (%) | 957 (1.8) | 11 (2.9) | 159 (2.7) | 603 (3.0) | 116 (2.8) | 84 (3.2) | <0.001 |
| Atrial fibrillation, n (%) | 7404 (42.2) | 84 (43.5) | 993 (50.4) | 3540 (52.4) | 796 (56.7) | 428 (49.5) | <0.001 |
| COPD, n (%) | 2471 (14.1) | 35 (18.1) | 307 (15.6) | 1176 (17.4) | 228 (16.2) | 152 (17.6) | <0.001 |
| Pulmonary hypertension, n (%) | 3495 (19.9) | 36 (18.7) | 488 (24.8) | 1781 (26.4) | 379 (27.0) | 247 (28.6) | <0.001 |
| Hypertension, n (%) | 11,222 (64.0) | 125 (64.8) | 1178 (59.8) | 4171 (61.8) | 897 (63.8) | 473 (54.7) | <0.001 |
| Diabetes, n (%) | 5038 (28.7) | 82 (42.5) | 710 (36.0) | 2746 (40.7) | 630 (44.8) | 401 (46.4) | <0.001 |
| Dialysis during hospital stay, n (%) | 572 (3.3) | 6 (3.1) | 82 (4.2) | 462 (6.8) | 228 (16.2) | 708 (81.8) | <0.001 |
P values for comparisons of baseline parameters between the five different CKD groups were calculated using the chi-squared test for categorical variables and one-way ANOVA for continuous variables. EuroSCORE, European System for Cardiac Operative Risk Evaluation; CAD, coronary artery disease; PAD, peripheral artery disease; NYHA, New York Heart Association; CABG, coronary artery bypass graft surgery; COPD, chronic obstructive lung disease.