Table 1.
Lipid–Drug Conjugates and Their Delivery Systems
| lipids | drugs | delivery systems |
|---|---|---|
| fatty acids | ||
| squalene | acyclovir | no carrier140 |
| gemcitabine | LDC nanoparticle,93,95–97 nanocomposite,132 liposome141 | |
| nucleoside analogue | LDC nanoparticle142 | |
| paclitaxel | lipid vesicle,116 self-assembled nanoparticle143 | |
| curcumin | nanoassembly144 | |
| siRNA | self-assembled nanoparticle73,145 | |
| adenosine | self-assembled nanoparticle146 | |
| doxorubicin | nanoassembly99 | |
| stearic acid | gemcitabine | polymer nanoparticle,53 lipid nanoparticle,2–4,7,125,147 micelle1,5 |
| 5-fluorouracil | lipid nanoparticle81 | |
| oleic acid | docetaxel | nanostructured lipid carrier84 |
| paclitaxel | emulsion104 | |
| palmitic acid | dexamethasone | emulsion39 |
| paclitaxel | immunoemulsion106 | |
| doxorubicin | micelle56 | |
| TGX-221 | micelle122 | |
| siRNA | polymer nanoparticle75 | |
| capecitibane | lipid nanoparticle43 | |
| DHA | doxorubicin | no carrier43 |
| 10-hydroxycamptothecin | no carrier69 | |
| paclitaxel | no carrier9,11 | |
| linoleic acid | paclitaxel | liposome119 |
| octadecanoic acid | gemcitabine | nanoassembly90,91 |
| lauric acid | cytarabine | self-assembled nanofiber68 |
| α-tocopherol | siRNA | no carrier64 |
| oligonucleotide | no carrier78 | |
| SN-38 | polymer nanoparticle48 | |
| steroids | ||
| cholesterol | 5-fluorouracil | no carrier13 |
| paclitaxel | lipid nanoparticle,16 lipophilic nanoparticle15 | |
| siRNA | no carrier,17,58,74 high-density lipoprotein14 | |
| ursodeoxycholic acid | zidovudine | polymer nanoparticle19,127 |
| lithocholic acid | tamoxifen | no carrier21 |
| glycerides | ||
| melphalan | liposome23,32 | |
| mycophenolic acid | lipid-based formulation24–26 | |
| mitomycin C | liposomes27–30 | |
| methotrexate | liposome23 | |
| testosterone | no carrier33 | |
| paclitaxel | polymer nanoparticle15 | |
| phospholipids | ||
| gemcitibane | liposome,36 no carrier34 | |
| chlorambucil | liposome35 | |