Table 2.
Sociodemographic and clinical characteristics of patients at baseline
| Overall study samplea | Analysis sub-sample | |
|---|---|---|
| N = 39,557 | N = 21,088 | |
| Age at Index Date, Mean ± SD [Median] | 42.1 ± 15.1 [42] | 43.3 ± 15.2 [43] |
| Female, N (%) | 24,150 (61.1) | 12,784 (60.6) |
| Region of Residence at Index Date, N (%) | ||
| West | 12,021 (30.4) | 6946 (32.9) |
| South | 11,764 (29.7) | 5798 (27.5) |
| North East | 10,474 (26.5) | 5530 (26.2) |
| North Central | 4773 (12.1) | 2572 (12.2) |
| Unknown | 525 (1.3) | 242 (1.1) |
| Type of Healthcare Plan at Index Date*, N (%) | ||
| PPO | 20,747 (52.4) | 10,834 (51.4) |
| HMO and POS with Capitation | 10,081 (25.5) | 5750 (27.3) |
| POS without Capitation and EPO | 4272 (10.8) | 2081 (9.9) |
| Comprehensive | 2605 (6.6) | 1438 (6.8) |
| CDHP and HDHP | 1354 (3.4) | 740 (3.5) |
| Unknown | 498 (1.3) | 245 (1.2) |
| Medicare Coverage at Index Date, N (%) | 2812 (7.1) | 1723 (8.2) |
| CCI during the 12-Month Baseline Period, Mean ± SD [Median]b, c | 0.4 ± 1.0 [0] | 0.4 ± 1.0 [0] |
| Antidepressant Initiated on the Index Date, N (%) | ||
| SSRI | 27,502 (69.5) | 15,048 (71.4) |
| SNRI | 4283 (10.8) | 2325 (11.0) |
| TCA | 403 (1.0) | 124 (0.6) |
| Other | 7369 (18.6) | 3591 (17.0) |
| All-Cause Healthcare Resource Utilization, Mean ± SD [Median] | ||
| Inpatient Admissions | 0.2 ± 0.6 [0] | 0.2 ± 0.5 [0] |
| Outpatient Visits | 12.2 ± 12.6 [8] | 12.1 ± 12.5 [8] |
| Emergency Room Visits | 0.4 ± 1.0 [0] | 0.3 ± 0.9 [0] |
| Other Medical Service Visits | 1.5 ± 3.9 [0] | 1.6 ± 4.1 [0] |
| Number of Visits to a Mental Health Professional, Mean ± SD [Median] | 1.9 ± 4.1 [1] | 1.8 ± 4.2 [1] |
| All-Cause Healthcare Costs (2014 USD), Mean ± SD [Median] | 9941 ± 48,697 [3375] | 9152 ± 23,965 [3230] |
*PPO = Preferred Provider Organization; HMO = Home Maintenance Organization; POS = Point of Service; EPO = Exclusive Provider Organization; CDHP = Consumer Directed Health Plan; HDHP = High Deductible Health Plan; CCI = Charlson-Quan Comorbidity Index; SD = standard deviation; SSRI = Selective serotonin reuptake inhibitor; SNRI = Serotonin-norepinephrine reuptake inhibitor; TCA = Tricyclic agent
aThe overall study sample was defined without restriction in terms of adequate treatment duration.
bQuan H, Sundararajan V, Halfon P et al. Coding Algorithms for Defining Comorbidities in ICD-9-CM and ICD-10 Administrative Data. Medical Care 2005;43:1130–1139. The CCI score is calculated based on dichotomous variables indicating whether or not a patient had the condition as follows: sum (myocardial infarction, congestive heart failure, peripheral vascular disease, cardiovascular disease, dementia, chronic pulmonary disease, rheumatologic disease, peptic ulcer disease, max[mild liver disease, 3*moderate liver disease], max[mild diabetes, 2*chronic diabetes], 2*hemiplegia, 2* renal disease, max [2* malignancy, 6* metastatic solid tumor], 6*AIDS)
cThe most common physical comorbidity during the baseline period was hypertension, observed in 7392 (18.7%) patients. The most common mental comorbidity during the baseline period was anxiety disorder, observed in 5698 (14.4%) patients