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. 2017 Jun 19;9:57. doi: 10.1186/s13073-017-0447-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Gastric organoid tumor model. Gastric organoids with the indicated genotypes are shown. a Tumor volumes were measured over time post-injection. Gastric organoids were dissociated and subcutaneously injected into the flanks of NOG mice. Cdh1 ^-/-;Trp53 ^-/- is shown in blue, and Cdh1 ^-/-;Trp53 ^-/-;FGFR2 is shown in red. Error bars represent SEM, and asterisks indicate p < 0.04. b Images indicate tumor growth at 50 days post-injection. c Overexpression of FGFR2 was confirmed in the tumor derived from Cdh1 ^-/-;Trp53 ^-/-;FGFR2 organoids. d–e Histological analysis of the Cdh1-/-;Trp53-/-;FGFR2 tumors confirms the presence of poorly differentiated adenocarcinoma with signet ring as indicated by arrows. f, g After flank injections with dissociated organoids, histological analysis of murine lungs after 50 days revealed metastatic gastric adenocarcinoma with signet ring features at low (f) and high (g) magnification