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. 2017 Jun 19;18:123. doi: 10.1186/s12931-017-0610-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — FE-derived parameters. Negative pressure-driven forced expiration maneuvers were performed at baseline and following each methacholine aerosol challenge (0 –20 mg/mL). Forced expiratory volume at 0.1 s, FEV_0.1 (a, c), forced vital capacity, FVC (b, d) are shown for LPS-ALI (a, b) and HDM-asthma (c, d). The mean (± SD) concentration-response curve of each group is represented together with that of the naive control group. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to naive controls. n = 7 –8 per group