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. 2016 Nov 29;7:13685. doi: 10.1038/ncomms13685

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Our findings support this working model to explain how PRC2 promotes proliferation and hypertrophy in the growth plate. In the proliferative zone (PZ), PRC2 suppresses expression of Cdk inhibitors Cdkn2a and 2b, to allow normal cell cycle progression and proliferation. In the hypertrophic zone (HZ), PRC2 positively modulates IGF signalling by suppressing the expression of Igfbp3 and 5, therefore promoting chondrocyte hypertrophy.