Figure 4. Chip-seq-based global analysis for transcriptional regulation via H3F3A.

(a) Genomic distribution of H3.3 ChIP-seq peaks in H3F3A-overexpressed A549 cells. (b) Correlation between H3.3 occupancy and target gene expression at intron, promoter and intergenic region. (c) H3.3 binding profile of intronic/promoter/intergenic peaks of three gene groups classified by the expression level (red: high expression group, yellow-green: intermediate expression group, blue: low expression group). (d) Association of H3.3 peaks with various histone marks.