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Effects of layer mutations on SNARE folding energy. Gray bars indicate the sum of the MD and NTD folding energies. Colored bars indicate energies of the combined domains denoted. All mutations are layer mutations in VAMP2, except the double mutations M71A and I192A in SNAP‐25 and T251I in syntaxin. Mutations highlighted in red correspond to impaired exocytosis. Reproduced from Ma et al.53
