Figure 7.

Different SNARE complexes share fast CTD folding, but exhibit different equilibrium forces and folding energies. (A) Extension‐time trajectories of two‐state CTD transitions in different SNARE complexes at different constant mean forces (F) near half unfolding probabilities (p). (B) CTD unfolding probability (symbol) as a function of force and its best model fit (solid curve). To compare folding dynamics of these SNARE complexes, we have used chimeric SNARE constructs in which the four SNARE motifs are joined into one polypeptide, which minimally interferes with CTD transitions and NTD unfolding. Adapted from Zorman et al.52