FIG 4.
Reduced muscle size and strength but maintenance of normalized force in HSACrePofut1FF muscles. (A and B) Mouse (A) and individual skeletal muscle (B) weights of HSACrePofut1FF mice and age- and gender-matched Pofut1FF mice. Muscles in panel B were weighed at 6 months of age. (C) Absolute grip strengths for forelimbs and hind limbs at different ages. (D) Extensor digitorum longus (EDL) muscles or strips of diaphragm muscle were excised and analyzed ex vivo for tetanic force normalized to muscle cross-sectional area. (E) Force drop during repeated eccentric contractions of EDL muscles. (F) Fatigue measures of diaphragm strips in response to repeated contractions. Error bars show SEM (n = 6 [A], 5 or 6 [B and C], 6 [D], or 7 or 8 [F] samples per condition). *, P < 0.05; **, P < 0.01, ***, P < 0.001.