TABLE 1.

Gene expression changes in aged HSACrePofut1^FF muscles suggest changed muscle fiber type composition, regeneration, and denervation^a

Gene category and name	Gene product	Fold change in expression
		HSACrePofut1FF vs HSACre	HSACrePofut1FF vs Pofut1FF
Fiber type
Myh6	Myosin heavy chain 6	9.3
Tnnt2	Troponin T2		6.2
Myh7a	Myosin heavy chain 7A		0.9
Muscle regeneration
Myh3	Myosin heavy chain 3	5.1	12.8
Myh8	Myosin heavy chain 8	4.3	6.0
Myl4	Myosin light chain 4	5.3	7.6
Igf2	Insulin-like growth factor 2	4.6	6.5
Myog	Myogenin		2.7
B4Galnt1	GM2/GD2 glycolipid synthase		2.5
Cdk6	Cyclin-dependent kinase 6	2.1	2.4
Lama2	Laminin α2	1.6	1.6
Lamb1	Laminin β1		2.1
Lamc1	Laminin γ1		1.7
Col4a1	Collagen IV (α1)		1.8
Col4a2	Collagen IV (α2)		1.7
Bgn	Biglycan	2.2	2.0
Muscle denervation
Ncam1	Neural cell adhesion molecule	2.9	2.7
Chrnd	Cholinergic receptor δ	2.2	2.6
Chrna1	Cholinergic receptor α1		2.7
Chrnb1	Cholinergic receptor β1		1.7
Sntb1	Syntrophin β1	2.5	2.0
Ache	Acetylcholinesterase		1.8

^aQuadriceps muscles from 17-month-old HSACrePofut1^FF, HSACre, and Pofut1^FF mice were compared by RNA-seq. Three samples per group were used, and average fold changes are reported.