TABLE 2.
GO analysis of mRNAs increased or decreased in La cKO relative to WT cortex
| Term | Function | P value |
|---|---|---|
| Increased | ||
| PANTHER | Response to stimulus | 1.21E−19 |
| Immune response | 4.79E−19 | |
| Immune system process | 5.34E−17 | |
| Response to organic substance | 1.68E−16 | |
| Positive regulation of biological process | 1.41E−15 | |
| DAVID | Immune response | 2.40735E−15 |
| Defense response | 4.20214E−13 | |
| Inflammatory response | 1.11918E−09 | |
| Response to wounding | 6.2233E−09 | |
| Innate immune response | 9.89764E−09 | |
| NOA | Response to stimulus | 3.30E−31 |
| Biological regulation | 1.80E−28 | |
| Immune system process | 1.50E−27 | |
| Regulation of biological process | 2.30E−27 | |
| Cellular process | 2.50E−25 | |
| Decreased | ||
| PANTHER | Generation of neurons | 3.36E−04 |
| Regulation of localization | 3.55E−04 | |
| Ion transport | 1.05E−03 | |
| Nervous system development | 7.10E−03 | |
| Regulation of apoptotic process | 2.15E−02 | |
| DAVID | Wnt receptor signaling pathway | 4.30E−04 |
| Ion transport | 8.50E−04 | |
| Cell-cell signaling | 1.50E−03 | |
| Neuron differentiation | 3.10E−03 | |
| Behavioral defense response | 4.80E−03 | |
| NOA | Cell junction | 4.20E−07 |
| Regulation of metabolic process | 5.80E−06 | |
| Ion channel activity | 3.20E−06 | |
| Behavioral fear response | 4.80E−03 | |
| Transmembrane transporter activity | 1.40E−04 |