FIG 7.

No effect of FHL2 deficiency on renal fibrosis. Kidneys were derived from naive or Leptospira-infected WT and Fhl2^−/− mice. Light microscopy of kidneys stained with H&E (A, B, E, F, I, J, M, and N) and collagen deposition stained with Sirius red (C, D, G, H, K, L, O, and P) is shown. Original magnifications, ×40 (A, C, E, G, I, K, M, and O) and ×100 (B, D, F, H, J, L, N, and P). (Q) Sirius red quantification. (R) TGF-β1 mRNA was analyzed by qPCR in kidneys from naive or Leptospira-infected WT and Fhl2^−/− mice. The data presented are the means and SD obtained from five mice in each group. *, P < 0.05.