Table 5. Correlation of gene polymorphisms of hOGG1, APE1 and XRCC1 with clinicopathological features of PACG patients.
| Clinicopathological features | hOGG1 Ser326Cys | APE1 Asp148Glu | XRCC1 Arg399Gln | |||
|---|---|---|---|---|---|---|
| Ser/Ser | Ser/Cys + Cys/Cys | Asp/Asp | Asp/Glu + Glu/Glu | Arg/Arg | Arg/Gln + Glu/Glu | |
| Gender | ||||||
| Male | 34 | 107 | 26 | 115 | 57 | 84 |
| Female | 24 | 93 | 18 | 99 | 46 | 71 |
| Age (years) | ||||||
| ≤60 | 28 | 113 | 25 | 116 | 58 | 83 |
| >60 | 30 | 87 | 19 | 98 | 45 | 72 |
| Diseased eye | ||||||
| Both eyes | 26 | 90 | 16 | 100 | 46 | 70 |
| One eye | 32 | 110 | 28 | 114 | 57 | 85 |
| Eyesight | ||||||
| ≤0.5 | 33 | 139 | 29 | 143 | 63 | 109 |
| >0.5 | 25 | 61 | 15 | 71 | 40 | 46 |
| Blood pressure | ||||||
| Systole (mmHg) | 141.9 ± 9.4 | 140.2 ± 8.2 | 143.0 ± 10.1 | 140.1 ± 8.2 | 141.5 ± 9.3 | 140.0 ± 8.2 |
| Diastole (mmHg) | 86.6 ± 6.7 | 86.0 ± 6.5 | 88.2 ± 8.0 | 85.9 ± 6.4 | 86.6 ± 7.0 | 85.8 ± 6.2 |
| Eye condition | ||||||
| Axial length (mm) | 25.4 ± 8.2 | 21.9 ± 7.5* | 26.1 ± 9.4 | 22.0 ± 7.5† | 24.06 ± 7.4 | 21.3 ± 7.5‡ |
| Corneal thickness (μm) | 527.9 ± 7.3 | 547.6 ± 10.2* | 523.3 ± 5.6 | 546.8 ± 10.1† | 532.1 ± 6.8 | 550.7 ± 9.4‡ |
| IOP (mmHg) | 20.2 ± 5.3 | 25.4 ± 7.1* | 20.1 ± 6.0 | 25.0 ± 7.0† | 20.7 ± 5.2 | 26.6 ± 7.1‡ |
*, P<0.05 in comparison with Ser/Ser wild-type genotype; †, P<0.05 in comparison with Asp/Asp wild-type genotype; ‡, P<0.05 in comparison with Arg/Arg wild-type genotype.