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. 2017 Apr 6;8(4):e2732. doi: 10.1038/cddis.2017.154

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ZEB1 is correlated with ER-α expression and ER-α DNA promoter hypermethylation in human breast tumors. (a) Representative images of immunohistochemical staining of ZEB1 and ER-α in two serial sections of the same tumor from four cases are shown. Scale bars, 50 μm. (b and c) The expression score (b, P=0.000, r=−0.272) and positive percentage analysis (c, P=0.000, r=-0.383) for ER-α indicate a negative correlation with ZEB1 expression in breast tumors from 248 subjects. Data were analyzed by Spearman's rank correction test. (d) DNA hypermethylation of the ER-α promoter is positively correlated with ZEB1 expression in 19 randomly selected samples. Data were analyzed by Spearman's rank correction test; P=0.000, r=0.535. (e and f) The expression score (e, P=0.001, r=−0.207) and positive percentage analysis (f, P=0.000, r=-0.252) for PR indicate a negative correlation with ZEB1 expression in breast tumors. Data were analyzed by Spearman's rank correction test. (g) The expression of ZEB1 is positively correlated with the histological grades of breast tumors. Data were analyzed by Spearman's rank correction test; P=0.043, r=0.129. (h) The expression of ER-α is negatively correlated with the histological grades of breast tumors. Data were analyzed by Spearman's rank correction test; P=0.021, r=−0.147