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. 2017 Apr 20;8(4):e2752. doi: 10.1038/cddis.2017.169

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The effect of BX-795 on p16 expression and cell senescence in vitro. (a) Representative β-gal staining images showing the effect of BX-795 on cell senescence after H₂O₂ (100 μM) stimulation 60 min in HEK293. (b) Statistical analysis of the data shown in (a).The data are expressed as the means±s.e.m.. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus H₂O₂. (c) Western blot showing the effect of BX-795 on p16 and cyclin A expression after H₂O₂ (100 μM) stimulation 60 min in HEK293. (d) Statistical analysis of the data shown in (c). The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus H₂O₂. (e) Representative β-gal staining images showing the effect of BX-795 on cell senescence after LPS (1 μg/ml) stimulation 90 min in HEK293. (f) Statistical analysis of the data shown in (e).The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus LPS. (g) Western blot showing the effect of BX-795 on p16 and cyclin A expression after LPS (1 μg/ml) stimulation 90 min in HEK293. (h) Statistical analysis of the data shown in (g). The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus LPS. (i) Representative β-gal staining images showing the effect of BX-795 on cell senescence after starvation in HEK293. (j) Statistical analysis of the data shown in (i).The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus starvation. (k) Western blot showing the effect of BX-795 on p16 and cyclin A expression after starvation stimulation. (l) Statistical analysis of the data shown in (k). The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus starvation