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. 2017 Apr 20;8(4):e2752. doi: 10.1038/cddis.2017.169

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The effect of TBK1 overexpression on Akt-Bmi pathway. (a) Western blot showing the effect of MK-2206 (1 μM) on Akt Ser473 and p16 expression after TBK1 overexpression in HEK293. (b, c) Statistical analysis of the data shown in (a).The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus TBK1. (d) Representative Co-IP results show the interactions of Bmi and phosphorylated serine after TBK1 overexpression in HEK293. (e) Western blot showing the effect of Bmi Ser316 mutation on p16 expression after TBK1 overexpression in HEK293. (f) Statistical analysis of the data shown in (e).The data are expressed as the means±s.e.m. from three independent experiments, *P<0.05 versus control, ^&P<0.05 versus TBK1, ^#P<0.05 versus TBK1+S316A