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. 2017 Apr 20;8(4):e2752. doi: 10.1038/cddis.2017.169

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Schematic representation of the contribution of TBK1 to RGC senescence after acute IOP elevation-induced ischemic retinas. Acute IOP elevation-induced ischemic retinas induces TBK1 up-regulation, which then increases Akt Ser473 and Bmi Ser316 phosphorylation, whereby upregulates p16 expression, finally induces RGC senescence