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. 2017 Apr 6;8(4):e2727. doi: 10.1038/cddis.2017.26

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A 1.0 kb hBAFF promoter activity was higher than 0.25 or 0.5 kb in MH7A cells. (a) The 0.25 and 0.5 kb pGL3-hBAFF-Luc plasmids were prepared by the deletion of 750 and 500 bp from the 5′-end of 1.0 kb hBAFF promoter, respectively. (b) The MH7A cells were transfected with 0.25, 0.5, or 1.0 kb pGL3-hBAFF-Luc plasmids and incubated in the presence or absence of TNF-α for 6 h. hBAFF promoter activity was measured as luciferase activity using luminometer. (c) pGL3-hBAFF-Luc and pSG5-HIF-1α plasmids were co-transfected into MH7A. Luciferase activity of hBAFF promoter was measured by using luminometer. Data were the representative of four experiments. Data in the bar graph represent the means±S.E.M. **P<0.01, significant difference as compared with 0.25 or 0.5 kb hBAFF-Luc-transfected group. ^##P<0.01, significant difference as compared with TNF-α-untreated control for each size of hBAFF promoter (b and c)