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. 2017 Apr 6;8(4):e2739. doi: 10.1038/cddis.2017.61

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MMP14 and ACTG1 overexpression enhances SW480 cell migration and adhesion by upregulating β-integrin. (a) Transwell migration assay of SW480 cells with overexpressing MMP14 and ACTG1. Above: representative images, the photomicrographs were taken at 100 × magnification. Below: quantitative results of three independent experiments (*P<0.05). (b) Adhesion assay of SW480 cells with overexpressing MMP14 and ACTG1. The number of adherent cells was estimated by reading the absorbance at 620 nm. Above: representative images, the photomicrographs were taken at × 100 magnification. Below: quantitative results of three independent experiments (*P<0.05). (c) Adhesion assay of SW480 cells transfected with the indicated siRNAs (*P<0.05, **P<0.01, NS, not significant). (d) The influence of MMP14 and ACTG1 on β-integrin protein expression in SW480 cells was determined by western blot (*P<0.05, **P<0.01, NS, not significant)