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. 2017 Apr 6;8(4):e2735. doi: 10.1038/cddis.2017.90

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Vitamin D3 analog MC903 induces AD. (a) Schematic of MC903 application. (b) Increase in ear thickness after daily MC903 treatment. (c and d) Photographs (c) and H&E staining (d) of MC903- and ethanol-treated ears at day 12. Scale bar represents 50 μm. (e) The infiltrating CD11b⁺ and CD11b⁺ Ly6G⁺ cells in skin of AD lesions by FACS. (f-n) The expression of MPO (f), LCN-2 (g), MMP-9 (h), IL-4 (i), IL-13 (j), IL-5 (k), eotaxin-2 (l) and TSLP (m and n) in the ear treated with ethanol or MC903. *P<0.05,**P<0.01,***P<0.001. P-values were analyzed by one-way ANOVA in b and m, two-tailed t-tests in e or two-way ANOVA in f-l and n. All data are representative of two to three independent experiments with n=5 per group and are means±S.E.M.