Table III.
Odd Ratios and 95% Confidence Intervals from Multivariable Models of Major and Minor ECG Abnormalities*
| Major ECG Abnormality | Minor ECG Abnormality† | |||
|---|---|---|---|---|
|
| ||||
| OR | (95% CI) | OR | 95% CI | |
|
| ||||
| Gender | ||||
| Female | 1.0 | 1.0 | ||
| Male | 1.2 | (0.9–1.5) | 1.6 | (1.4–1.9) |
| Race | ||||
| White | 1.0 | 1.0 | ||
| Black | 1.4 | (0.9–2.0) | 1.3 | (0.9–1.6) |
| Other | 0.9 | (0.3–2.9) | 0.9 | (0.5–1.7) |
| Body Mass Index (mg/kg2)‡ | 0.9 | (0.9–1.0) | 0.9 | (0.9–1.0) |
| Age at diagnosis‡ | 0.9 | (0.9–1.0) | 0.9 | (0.9–1.0) |
| Age at Evaluation | ||||
| 18–29 years | 1.0 | 1.0 | ||
| 30–39 years | 1.1 | (0.8–1.5) | 0.9 | (0.7–1.1) |
| 40–49 years | 1.3 | (0.9–2.0) | 1.2 | (0.9–1.6) |
| ≥ 50 years | 1.9 | (0.9–3.7) | 1.7 | (0.8–3.4) |
| Anthracycline (mg/m2) | ||||
| None | 1.0 | 1.0 | ||
| 1 – 300 | 1.3 | (0.9–1.8) | 1.0 | (0.8–1.3) |
| ≥ 300 | 1.7 | (1.1–2.5) | 1.1 | (0.8–1.5) |
| Alkylating agents (mg/m2) | ||||
| None | NE | 1.0 | ||
| 1 – 9000 | 1.1 | (0.9–1.3) | ||
| ≥ 9000 | 1.3 | (1.0–1.6) | ||
| Cardiac Radiation (cGy) | ||||
| None | 1.0 | 1.0 | ||
| 1–1999 | 2.1 | (1.5–2.9) | 1.4 | (1.1–1.8) |
| 2000–2999 | 2.6 | (1.6–3.9) | 1.7 | (1.2–2.4) |
| ≥ 3000 | 10.5 | (6.5–16.9) | 4.9 | (2.1–11.7) |
| Hypertension | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.6 | (1.2–2.1) | 1.3 | (1.0–1.6) |
| Smoking | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.1 | (0.8–1.4) | 1.2 | (0.9–1.4) |
| Dyslipidemia | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.0 | (0.8–1.4) | 1.0 | (0.8–1.2) |
| Diabetes | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.4 | (0.9–2.2) | 1.0 | (0.7–1.5) |
*
Estimates adjusted for all variables in the table
†
among 2,425 survivors without major abnormalities
‡
Continuous variables
NE=not estimated, p-value >0.2 on univariate analysis