Fig. 1. Targeting the Cyclin D–CDK 4/6–INK4–Rb pathway.
CDK cyclin-dependent kinase, E2F E2 transcription factor, ER estrogen receptor, GRB2 growth factor receptor-bound protein 2, HR+ hormone receptor-positive, mTOR mammalian target of rapamycin, PI3K phosphatidylinositol 3-kinase, Rb retinoblastoma, RTK receptor tyrosine kinase, S6K S6 kinase