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IC50 values of CDK 4/6 inhibitors
| IC50 (nM) | |||
|---|---|---|---|
|
| |||
| Palbociclib (Fry et al., 2004) | Ribociclib (Kim et al., 2013) | Abemaciclib (Gelbert et al., 2014) | |
|
| |||
| CDK4-cyclin D1 | 11 | 10 | 2 |
| CDK6-cyclin D1/2/3 | 16 | 39 | 10 |
| CDK1-cyclin B | >10,000 | 113,000 | 1627 |
| CDK2-cyclin A/E | >10,000 | 76,000 | 504 |
| CDK9-cyclin T | NR | NR | 57 |
NR not reported
